An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. To help avoid interactions, your doctor should manage all of your medications carefully. Taking ketoconazole with solifenacin can increase the amount of solifenacin in your body. This may lead to more side effects. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.
Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Taking it again could be fatal cause death.
The use of drinks that contain alcohol can make your bladder symptoms worse. If you drink alcohol, talk to your doctor. Use this drug with caution if you have other problems emptying your bladder. This may increase your risk of urinary retention. Use this drug with caution if you have delayed or slow emptying of your stomach.
This may increase your risk of gastric retention. For people with narrow-angle glaucoma: Use this drug with caution if you have an eye disorder called narrow-angle glaucoma. For people with liver issues: This drug is processed by your liver. If you have liver problems, more of the drug may stay in your body longer, putting you at risk for side effects.
Use this medication with caution. Your doctor may lower your dose and may check your liver function during treatment. For people with kidney issues: This drug is processed by your kidneys. If you have kidney problems, more of the drug may stay in your body longer, putting you at risk for side effects. Your doctor may lower your dose and may check your kidney function during treatment.
For people with an irregular heart rate: Use this drug with caution if you have QT prolongation irregular heart rate. For pregnant women: This drug is a category C pregnancy drug. That means two things:. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the pregnancy.
If it does, it may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication. In this article About solifenacin Before taking solifenacin How to take solifenacin Getting the most from your treatment Can solifenacin cause problems? How to store solifenacin Important information about all medicines.
Solifenacin tablets Vesicare, Giraxine, Vesomni In this article About solifenacin Before taking solifenacin How to take solifenacin Getting the most from your treatment Can solifenacin cause problems? Very common solifenacin side-effects these affect more than 1 in 10 people What can I do if I experience this? Dry mouth Try chewing sugar-free gum or sucking sugar-free sweets Common solifenacin side-effects these affect fewer than 1 in 10 people What can I do if I experience this?
Blurred vision Do not drive and do not use tools or machines while affected Feeling sick nausea , indigestion, tummy abdominal pain, stomach discomfort Eat simple meals - avoid rich or spicy foods Constipation Try to eat a well-balanced diet and drink several glasses of water each day. If you have any questions about this medicine ask your pharmacist. Are you protected against flu? Further reading and references. Join the discussion on the forums.
Health Tools Feeling unwell? Assess your symptoms online with our free symptom checker. Conflicts of interest Ramandeep Basra has no conflicts of interest.
National Center for Biotechnology Information , U. Ther Clin Risk Manag. Published online Feb. Ramandeep Basra and Con Kelleher. Author information Copyright and License information Disclaimer. All rights reserved. This article has been cited by other articles in PMC. Abstract Overactive bladder OAB is a prevalent condition which has an adverse effect on quality of life.
Keywords: solifenacin, urinary incontinence, overactive bladder. Pathology of overactive bladder The etiology of OAB is multifactorial. Antimuscarinic agents Older antimuscarinic agents such as oxybutynin are neither bladder nor muscarinic receptor subtype selective and are thus associated with greater generalized anticholinergic side effects.
Pharmacokinetics of solifenacin In drug development solifenacin has been shown to have functional selectivity for the bladder over other organs in animal models. Clinical efficacy Solifenacin is available in 2 dosage strengths namely a 5 or 10 mg once-daily tablet which can be taken with or without food. Clinical trials There have been several large, randomized clinical trials evaluating the efficacy, safety, tolerability, and persistence with solifenacin Table 1.
Table 1 Clinical trials evaluating the efficacy of solifenacin in the treatment of overactive bladder. Clinical trial phase Trial design Duration months Primary outcome measure Secondary outcome measures Quality of life assessment 2 Dose finding study.
Randomized, single-blind placebo- and tolterodine-controlled trial. Open in a separate window. Figure 1. Changes in bladder diary variables in a phase 2, solifenacin dose finding study.
Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. Conclusion Solifenacin was launched in as the first once-daily, flexible-dose, M3-receptor-selective antimuscarinic for the treatment of OAB. Footnotes Conflicts of interest Ramandeep Basra has no conflicts of interest. Overactive bladder significantly affects quality of life.
Am J Manag Care. Neurourol Urodyn. M2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder. Am J Physiol. Can medication prolong warning time [poster]. Randomized, double-blind placebo controlled trial of the once daily antimuscarinic agent solifenacin succinate in patients with overactive bladder. J Urol. Solifenacin significantly reduces both urgency severity and bother: Results from the flexible dose, placebo controlled, multinational Sunrise study.
Solifenacin in the treatment of urgency symptoms of overactive bladder in a flexible dose, placebo controlled trial. Recognizing warning time: a critical step towards continence. Geriatr Nurs. Muscarinic receptor antagonists in the treatment of overactive bladder. Solifenacin appears effective and well tolerated in patients with symptomatic idiopathic detrusor overactivity in a placebo- and tolterodine-controlled phase 2 dose-finding study.
BJU Int. Randomized, double-blind placebo-and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder. A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome: results of the STAR trial. Eur Urol. Epub Jan 5. In vitro tissue selectivity profile of solifenacin succinate YM for urinary bladder over salivary gland in rats and monkeys [poster].
ICS; Florence Italy. Functional role of M2 and M3 receptors in the urinary bladder of rats in vivo and in vitro.
Br J Pharmacol. Muscarinic receptor subtypes modulating smooth muscle contractility in the urinary bladder. Life Sci. Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: Results of the EPIC study.
Differential effects of the antimuscarinic agents darifenacin and oxybutynin ER on memory in older subjects. Epub Apr Improved quality of life in patients with overactive bladder symptoms treated with solifenacin.
A medium term analysis of the subjective efficacy of treatment for women with detrusor instability and low bladder compliance. Br J Obstet Gynaecol. A new questionnaire to assess the quality of life of urinary incontinent women.
How widespread are the symptoms of overactive bladder and how are they managed? A population-based prevalence study. Torsades de pointes occurring in association with terfenadine use. In vivo bladder selective profile of solifenacin succinate YM over salivary gland in mice and rats [poster]. Europe BV: Yamanouchi; Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Do not dispose of medications in wastewater e.
Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses.
Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. Many of these side effects can be managed, and some may go away on their own over time. Contact your doctor if you experience these side effects and they are severe or bothersome.
Your pharmacist may be able to advise you on managing side effects. Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention. Stop taking the medication and seek immediate medical attention if any of the following occur:.
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication. Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health.
These factors may affect how you should use this medication. Abnormal heart rhythm: Solifenacin may cause a heart rhythm disturbance called QT prolongation.
If you have a history of QT prolongation or are taking certain medications e. Bladder outflow obstruction: If you have a medical problem that obstructs the flow of urine from the bladder e. If you have a problem with urinary flow, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
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